Open AccessIntrinsic connections between thalamic sub-regions and the lateral prefrontal cortex are differentially impacted by acute methylphenidate
Author(s) -
Adam X. Gorka,
Tiffany R. Lago,
Nicholas L. Balderston,
Salvatore Torrisi,
Bari Fuchs,
Christian Grillon,
Monique Ernst
Publication year - 2020
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-020-05505-z
Subject(s) - prefrontal cortex , neuroscience , thalamus , methylphenidate , working memory , psychology , dopamine , functional magnetic resonance imaging , dopaminergic , cognition , attention deficit hyperactivity disorder , psychiatry
The thalamus is a major target of dopaminergic projections and is densely connected with the prefrontal cortex. A better understanding of how dopamine changes thalamo-cortical communication may shed light on how dopamine supports cognitive function. Methylphenidate has been shown to facilitate cognitive processing and reduce connectivity between the thalamus and lateral prefrontal cortex.