Open AccessKappa opioid agonists reduce oxycodone self-administration in male rhesus monkeys
Author(s) -
C. Austin Zamarripa,
Naylor Je,
Huskinson Sl,
Townsend Ea,
Thomas E. Prisinzano,
Freeman Kb
Publication year - 2020
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-020-05473-4
Subject(s) - oxycodone , self administration , agonist , pharmacology , κ opioid receptor , opioid , antagonist , analgesic , saline , partial agonist , medicine , chemistry , anesthesia , receptor
Combinations of mu and kappa opioid receptor (KOR) agonists have been proposed as potential analgesic formulations with reduced abuse liability. The current studies extend previous work by investigating the typical KOR agonist, salvinorin A, and the atypical KOR agonist, nalfurafine, as deterrents of oxycodone self-administration using a progressive ratio (PR) schedule of reinforcement.