Open AccessMethamphetamine increases dopamine release in the nucleus accumbens through calcium-dependent processes
Author(s) -
Jordan T. Yorgason,
David M. Hedges,
J. Daniel Obray,
Eun Young Jang,
Kyle B. Bills,
Mark Woodbury,
Benjamin M. Williams,
Mandy Parsons,
Míriam Andrés,
Scott C. Steffensen
Publication year - 2020
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-020-05459-2
Subject(s) - intracellular , nucleus accumbens , meth , extracellular , chemistry , methamphetamine , dopamine , pharmacology , biophysics , calcium in biology , receptor , endocrinology , biochemistry , biology , monomer , organic chemistry , acrylate , polymer
Methamphetamine (METH) enhances exocytotic dopamine (DA) signals and induces DA transporter (DAT)-mediated efflux in brain striatal regions such as the nucleus accumbens (NAc). Blocking sigma receptors prevents METH-induced DA increases. Sigma receptor activation induces Ca 2+ release from intracellular stores, which may be responsible for METH-induced DA increases.