Open AccessFluoxetine effects on behavior and adult hippocampal neurogenesis in female C57BL/6J mice across the estrous cycle
Author(s) -
Christine N. Yohn,
Sophie Shifman,
Alexander Garino,
Emma J Diethorn,
Leshya Bokka,
Sandra A. Ashamalla,
Benjamin Adam Samuels
Publication year - 2020
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-020-05456-5
Subject(s) - neurogenesis , estrous cycle , fluoxetine , hippocampal formation , serotonin reuptake inhibitor , behavioural despair test , psychology , endocrinology , dentate gyrus , medicine , reuptake inhibitor , neuroscience , antidepressant , serotonin , hippocampus , receptor
Some mood disorders, such as major depressive disorder, are more prevalent in women than in men. However, historically preclinical studies in rodents have a lower inclusion rate of females than males, possibly due to the fact that behavior can be affected by the estrous cycle. Several studies have demonstrated that chronic antidepressant treatment can decrease anxiety-associated behaviors and increase adult hippocampal neurogenesis in male rodents.