Open AccessBehavioral pharmacology of the mixed-action delta-selective opioid receptor agonist BBI-11008: studies on acute, inflammatory and neuropathic pain, respiration, and drug self-administration
Author(s) -
Glenn W. Stevenson,
Denise Giuvelis,
James Cormier,
Katherine Cone,
Phillip Atherton,
Rebecca Krivitsky,
Emily Warner,
B. Laurent,
Julio Dutra,
Jean M. Bidlack,
Lajos Szabó,
Robin Polt,
Edward J. Bilsky
Publication year - 2020
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-019-05449-z
Subject(s) - pharmacology , neuropathic pain , morphine , medicine , opioid , analgesic , agonist , nociception , anesthesia , receptor
The present study characterized the behavioral pharmacology of a novel, mixed-action delta-selective (78:1) opioid receptor agonist, BBI-11008. This glycopeptide drug candidate was tested in assays assessing antinociception (acute, inflammatory, and neuropathic pain-like conditions) and side-effect endpoints (respiratory depression and drug self-administration).