Open AccessNeural correlates of oxytocin and cue reactivity in cocaine-dependent men and women with and without childhood trauma
Author(s) -
Jane E. Joseph,
Aimee L. McRaeClark,
Brian J. Sherman,
Nathaniel L. Baker,
Megan Moran-Santa Maria,
Kathleen T. Brady
Publication year - 2019
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-019-05360-7
Subject(s) - oxytocin , amygdala , psychology , placebo , reactivity (psychology) , cue reactivity , cocaine dependence , craving , addiction , clinical psychology , medicine , psychiatry , neuroscience , alternative medicine , pathology
Women with cocaine use disorder have worse treatment outcomes compared with men. Sex differences in cocaine addiction may be driven by differences in neurobiology or stress reactivity. Oxytocin is a potential therapeutic for stress reduction in substance use disorders, but no studies have examined the effect of oxytocin on neural response to drug cues in individuals with cocaine use disorders or potential sex differences in this response.