Open AccessEffects of haloperidol on the delta-9-tetrahydrocannabinol response in humans: a responder analysis
Author(s) -
Swapnil Gupta,
João P. De Aquino,
Deepak Cyril D’Souza,
Mohini Ranganathan
Publication year - 2019
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-019-05235-x
Subject(s) - psychotomimetic , haloperidol , delta 9 tetrahydrocannabinol , placebo , positive and negative syndrome scale , psychology , psychosis , schizophrenia (object oriented programming) , pharmacology , hallucinogen , dopaminergic , tetrahydrocannabinol , medicine , anesthesia , cannabinoid , dopamine , psychiatry , nmda receptor , receptor , alternative medicine , pathology
Δ-9-Tetrahydrocannabinol (Δ-9-THC) produces psychotomimetic effects in humans. However, the role of dopamine signaling in producing such effects is unclear. We hypothesized that dopaminergic antagonism would reduce the psychotomimetic effect of Δ-9-THC.