Open AccessInfluence of phendimetrazine maintenance on the reinforcing, subjective, performance, and physiological effects of intranasal cocaine
Author(s) -
William W. Stoops,
Justin C. Strickland,
Joseph L. Alcorn,
Lon R. Hays,
Abner O. Rayapati,
Joshua A. Lile,
Craig R. Rush
Publication year - 2019
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-019-05227-x
Subject(s) - cocaine abuse , psychology , cocaine dependence , placebo , heart rate , self administration , reinforcement , addiction , medicine , anesthesia , nasal administration , monoamine neurotransmitter , drugs of abuse , pharmacology , psychiatry , blood pressure , serotonin , social psychology , alternative medicine , receptor , pathology
No pharmacotherapies are approved for cocaine use disorder. Phendimetrazine, a prodrug of the monoamine-releaser phenmetrazine, attenuates the reinforcing effects of cocaine in preclinical models, has minimal abuse potential, and is safe when combined with cocaine.