Open AccessTargeting neuroinflammation with minocycline in heavy drinkers
Author(s) -
Ismene L. Petrakis,
Elizabeth Ralevski,
Ralitza Gueorguieva,
Matthew E. Sloan,
Lesley Devine,
Gihyun Yoon,
Albert J. Arias,
Mehmet Sofuoglu
Publication year - 2019
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-019-05205-3
Subject(s) - minocycline , neuroinflammation , pharmacology , placebo , ethanol , medicine , microglia , cytokine , craving , inflammation , anesthesia , immunology , antibiotics , chemistry , pathology , psychiatry , biochemistry , addiction , alternative medicine
Alcohol has both acute and chronic effects on neuroimmune signaling, including triggering pro-inflammatory cytokine release by microglia. Minocycline, a second-generation tetracycline antibiotic, inhibits microglial activation and reduces neuroinflammation in preclinical studies. In mice, minocycline also reduces ethanol intake, attenuates ethanol-induced conditioned place preference, and inhibits ethanol-induced microglial activation and pro-inflammatory cytokine release.