Open AccessMinocycline does not affect experimental pain or addiction-related outcomes in opioid maintained patients
Author(s) -
Caroline Arout,
Andrew J. Waters,
R. Ross MacLean,
Peggy Compton,
Mehmet Sofuoglu
Publication year - 2018
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-018-5146-7
Subject(s) - minocycline , affect (linguistics) , addiction , opioid , opioid addiction , medicine , psychology , psychiatry , pharmacology , clinical psychology , chemistry , receptor , antibiotics , biochemistry , communication
Minocycline, a tetracycline antibiotic, inhibits activation of microglia. In preclinical studies, minocycline prevented development of opioid tolerance and opioid-induced hyperalgesia (OIH). The goal of this study was to determine if minocycline changes pain threshold and tolerance in individuals with opioid use disorder who are maintained on agonist treatment.