Open AccessReduction in delay discounting due to nicotine and its attenuation by cholinergic antagonists in Lewis and Fischer 344 rats
Author(s) -
Jenny E. Ozga,
Karen G. Anderson
Publication year - 2017
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-017-4752-0
Subject(s) - mecamylamine , nicotine , antagonist , nicotinic agonist , pharmacology , endocrinology , antagonism , cholinergic , acetylcholine , competitive antagonist , agonist , medicine , chemistry , anesthesia , receptor
Nicotine acts as an agonist for nicotinic acetylcholine receptors (nAChRs), and mecamylamine, a nonselective nAChR antagonist, attenuates effects of nicotine on delay discounting in some rat strains; whether nicotine's attenuation is specific to nAChR antagonism is unknown.