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Hypotension in brain-dead organ donors is considered a determinant factor of graft viability. The aim of this study was to elucidate the role of hypotension in brain-death associated impairment of hepatic microcirculation and function. Male Sprague-Dawley rats with an intracranial balloon were used. Group I (n = 7) served as sham controls. In group II (n = 7) brain death was induced through inflation of an intracranial balloon. In group III (n = 7) hypotension without brain death was induced by means of pentobarbital. In group II, a steep rise of arterial pressure was followed by a fall to a lower level (P &lt; 0.01, vs. group I). Also in group III arterial pressure was lower (P &lt; 0.01, vs. group I). In group II, bile production was diminished (P &lt; 0.05). Impaired sinusoidal perfusion (P &lt; 0.01) and enhanced leukocyte endothelium interaction (P &lt; 0.05) were documented in hepatic microvasculature. Electron microscopic analysis revealed vacuolization of hepatocytes; these changes were not observed in group III. Brain death induces specific changes of liver microcirculation, function and histomorphology. Independent of associated hypotension, brain death per se impairs donor liver graft quality.

Role of hypotension in brain-death associated impairment of liver microcirculation and viability