Normothermic recirculation reduces primary graft dysfunction of kidneys obtained from non-heart-beating donors | Zendy

R. Valero | Zendy; C Cabrer | Zendy; F. Oppenheimer | Zendy; Esteve Trias | Zendy; Jacinto Sánchez Ibáñez | Zendy; Francisco M. De Cabo | Zendy; Aurora Navarro | Zendy; David Paredes | Zendy; Antonio Alcaraz | Zendy; Rafael Gutiérrez | Zendy; Martí Manyalich | Zendy

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Normothermic recirculation reduces primary graft dysfunction of kidneys obtained from non-heart-beating donors

Author(s) -

R. Valero,

C Cabrer,

F. Oppenheimer,

Esteve Trias,

Jacinto Sánchez Ibáñez,

Francisco M. De Cabo,

Aurora Navarro,

David Paredes,

Antonio Alcaraz,

Rafael Gutiérrez,

Martí Manyalich

Publication year - 2000

Publication title -

transplant international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.998

H-Index - 82

eISSN - 1432-2277

pISSN - 0934-0874

DOI - 10.1007/s001470050706

Subject(s) - medicine , urology , incidence (geometry) , organ procurement , perfusion , kidney , renal function , machine perfusion , surgery , cardiology , transplantation , physics , optics , liver transplantation

Our aim was to analyze the short- and long-term function of kidneys procured from non- heartbeating donors (NHBD) by means of three techniques: in situ perfusion (ISP), total body cooling (TBC) and normothermic recirculation (NR). Fifty-seven potential NHBD were included. Mean warm ischemia time was 68.9 +/- 35.6 min. Forty-four kidneys were obtained from donors perfused with ISP, 8 with TBC, and 8 with NR. Eighteen kidneys (32%) started functioning immediately, 29 (52%) showed delayed graft function (DGF) and 9 (16%) showed primary non function (PNF). The actuarial graft survival rate was 76.4% at 1 year and 56% at 5 years. The patient survival rate was 89.3% at 5 years. Incidence of DGF and PNF was significantly lower in kidneys perfused with NR than those with ISP or TBC (P < 0.01). Duration of DGF was shorter in kidneys obtained through TBC than in kidneys obtained with ISP (P < 0.05). In conclusion, NR reduces the incidence of DGF and may be considered the method of choice for kidney procurement from NHBD.

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