Systemic liberation of interleukin-8 in the perioperative phase of liver transplantation | Zendy

J. Gerlach | Zendy; Achim J�rres | Zendy; Michael Sch�n | Zendy; Roland Nohr | Zendy; Axel Berger | Zendy; Gabriele Spatkowski | Zendy; Mark D. Smith | Zendy; P. Neuhaus | Zendy

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Systemic liberation of interleukin-8 in the perioperative phase of liver transplantation

Author(s) -

J. Gerlach,

Achim J�rres,

Michael Sch�n,

Roland Nohr,

Axel Berger,

Gabriele Spatkowski,

Mark D. Smith,

P. Neuhaus

Publication year - 1997

Publication title -

transplant international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.998

H-Index - 82

eISSN - 1432-2277

pISSN - 0934-0874

DOI - 10.1007/s001470050079

Subject(s) - medicine , liver transplantation , perioperative , transplantation , interleukin , cytokine , interleukin 6 , gastroenterology , anesthesia , urology , surgery

Serum levels of interleukin-8 (IL-8) were investigated in the perioperative phase of liver transplantation (LTx) in order to help determine whether this cytokine might serve as a parameter for preservation injury. In a study of 45 patients undergoing LTx, systemic IL-8 was estimated at the end of the anhepatic phase, at 30, 60, and 120 min after reperfusion of the graft, and 24 h and 7 days after LTx. A maximum mean concentration of 665 +/- 135 pg/ml was seen 60 min after LTx. The minimum was found on the 1st postoperative day (POD 1): 328 +/- 33 pg/ml. Significant changes were found between 60 min and PODs 1 and 7, as well as between 120 min and POD 1. Differences in cold ischemia time were not found to be significant. We conclude that monitoring of systemic IL-8 levels is not useful in the development of new liver preservation concepts.

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