A novel mechanism regulating insulin secretion involving Herpud1 in mice | Zendy

Nicole Wong | Zendy; Grant Morahan | Zendy; Maria Stathopoulos | Zendy; Joseph Proietto | Zendy; Sofianos Andrikopoulos | Zendy

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A novel mechanism regulating insulin secretion involving Herpud1 in mice

Author(s) -

Nicole Wong,

Grant Morahan,

Maria Stathopoulos,

Joseph Proietto,

Sofianos Andrikopoulos

Publication year - 2013

Publication title -

diabetologia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.464

H-Index - 227

eISSN - 1432-0428

pISSN - 0012-186X

DOI - 10.1007/s00125-013-2908-y

Subject(s) - insulin , endocrinology , medicine , endoplasmic reticulum , biology , pancreatic islets , diabetes mellitus , unfolded protein response , gene , secretion , islet , microbiology and biotechnology , genetics

Type 2 diabetes results from beta cell dysfunction after prolonged physiological stress, which causes oversecretion of insulin. We recently found that insulin hypersecretion is mediated by at least two genes. Among mouse models of type 2 diabetes, the DBA/2 mouse strain is more susceptible to diabetes than is the C57BL/6J (B6J) strain. One distinctive feature of the DBA/2 mouse is that it hypersecretes insulin, independent of changes in insulin sensitivity; we identified Nnt as a gene responsible for this trait.

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