Open AccessTargeting CSPG4 for isolation of melanoma cell-derived exosomes from body fluids
Author(s) -
Soldano Ferrone,
Theresa L. Whiteside
Publication year - 2020
Publication title -
hno
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.438
H-Index - 36
eISSN - 1433-0458
pISSN - 0017-6192
DOI - 10.1007/s00106-019-00811-1
Subject(s) - microvesicles , melanoma , medicine , immune system , chondroitin sulfate proteoglycan , cancer research , cell , exosome , immunology , proteoglycan , microbiology and biotechnology , microrna , biology , anatomy , cartilage , biochemistry , gene
This manuscript describes the functional properties of the exosomes released from melanoma cells. It details the characteristics of the tumor antigen chondroitin sulfate proteoglycan 4 (CSPG4), which is used as a marker to separate exosomes released by melanoma cells from exosomes released by nonmalignant cells. The results are discussed in view of the potential role of melanoma cell-derived exosomes in the escape of malignant cells from the host's immune system.