Targeting CSPG4 for isolation of melanoma cell-derived exosomes from body fluids | Zendy

Soldano Ferrone | Zendy; Theresa L. Whiteside | Zendy

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Targeting CSPG4 for isolation of melanoma cell-derived exosomes from body fluids

Author(s) -

Soldano Ferrone,

Theresa L. Whiteside

Publication year - 2020

Publication title -

hno

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.438

H-Index - 36

eISSN - 1433-0458

pISSN - 0017-6192

DOI - 10.1007/s00106-019-00811-1

Subject(s) - microvesicles , melanoma , medicine , immune system , chondroitin sulfate proteoglycan , cancer research , cell , exosome , immunology , proteoglycan , microbiology and biotechnology , microrna , biology , anatomy , cartilage , biochemistry , gene

This manuscript describes the functional properties of the exosomes released from melanoma cells. It details the characteristics of the tumor antigen chondroitin sulfate proteoglycan 4 (CSPG4), which is used as a marker to separate exosomes released by melanoma cells from exosomes released by nonmalignant cells. The results are discussed in view of the potential role of melanoma cell-derived exosomes in the escape of malignant cells from the host's immune system.

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