Open AccessAn autoimmune-based, paraneoplastic neurologic syndrome following checkpoint inhibition and concurrent radiotherapy for merkel cell carcinoma: case report
Author(s) -
Alexander D. Sherry,
Michael Bezzerides,
Mohamed H. Khattab,
Guangcheng Luo,
Kristin K. Ancell,
Austin N. Kirschner
Publication year - 2020
Publication title -
strahlentherapie und onkologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 68
eISSN - 1439-099X
pISSN - 0179-7158
DOI - 10.1007/s00066-020-01582-3
Subject(s) - medicine , merkel cell carcinoma , radiation therapy , merkel cell , dermatology , carcinoma , oncology , pathology
Merkel cell carcinoma is highly sensitive to both radiation and immunotherapy. Moreover, concurrent radioimmunotherapy may capitalize on anti-tumor immune activity and improve Merkel cell treatment response, although an enhanced immune system may cross-react with native tissues and lead to significant sequelae.