Open AccessEpsins in vascular development, function and disease
Author(s) -
Sudarshan Bhattacharjee,
Yang Lee,
Bo Zhu,
Hao Wu,
Yabing Chen,
Hong Chen
Publication year - 2020
Publication title -
cellular and molecular life sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.928
H-Index - 223
eISSN - 1420-9071
pISSN - 1420-682X
DOI - 10.1007/s00018-020-03642-4
Subject(s) - lymphangiogenesis , angiogenesis , endocytosis , microbiology and biotechnology , biology , signal transducing adaptor protein , function (biology) , signal transduction , receptor , vascular endothelial growth factor c , vascular endothelial growth factor a , vascular endothelial growth factor , cancer research , genetics , metastasis , vegf receptors , cancer
Epsins are a family of adaptor proteins involved in clathrin-dependent endocytosis. In the vasculature, epsins 1 and 2 are functionally redundant members of this family that are expressed in the endothelial cells of blood vessels and the lymphatic system throughout development and adulthood. These proteins contain a number of peptide motifs that allow them to interact with lipid moieties and a variety of proteins. These interactions facilitate the regulation of a wide range of cell signaling pathways. In this review, we focus on the involvement of epsins 1 and 2 in controlling vascular endothelial growth factor receptor signaling in angiogenesis and lymphangiogenesis. We also discuss the therapeutic implications of understanding the molecular mechanisms of epsin-mediated regulation in diseases such as atherosclerosis and diabetes.