Open AccessTherapeutic treatment of dietary docosahexaenoic acid for particle-induced pulmonary inflammation in Balb/c mice
Author(s) -
Paige Fletcher,
Raymond F. Hamilton,
Joseph F. Rhoderick,
Britten Postma,
Mary Buford,
James J. Pestka,
Andrij Holian
Publication year - 2021
Publication title -
inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.121
H-Index - 89
eISSN - 1420-908X
pISSN - 1023-3830
DOI - 10.1007/s00011-021-01443-4
Subject(s) - docosahexaenoic acid , inflammation , lung , polyunsaturated fatty acid , medicine , histopathology , immunology , pharmacology , pathology , chemistry , fatty acid , biochemistry
The omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) has been reported to suppress inflammation. Pulmonary inflammation can be directly linked to exposure of various occupational and man-made particles leading to pulmonary diseases. Therapeutic treatments are lacking for particle-induced pulmonary inflammation. These studies evaluated DHA as a therapeutic treatment for semi-acute and chronic particle-induced pulmonary inflammation.