Open AccessCHRFAM7A reduces monocyte/macrophage migration and colony formation in vitro
Author(s) -
Theresa W. Chan,
Simone Langness,
Omri Cohen,
Brian P. Eliceiri,
Andrew Baird,
Todd W. Costantini
Publication year - 2020
Publication title -
inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.121
H-Index - 89
eISSN - 1420-908X
pISSN - 1023-3830
DOI - 10.1007/s00011-020-01349-7
Subject(s) - chemotaxis , monocyte , microbiology and biotechnology , in vitro , thp1 cell line , cell migration , cell culture , biology , cell adhesion , macrophage , receptor , cell , chemistry , immunology , biochemistry , genetics
CHRFAM7A is a unique human gene that encodes a dominant negative inhibitor of the α7 nicotinic acetylcholine receptor. We have recently shown that CHRFAM7A is expressed in human leukocytes, increases cel-cell adhesion, and regulates the expression of genes associated with leukocyte migration.