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Prenatal Diagnosis of Cystic Fibrosis Using Closely Linked DNA Probes
Author(s) -
Lissens W.,
Vercammen M.,
Foulon W.,
De Catte L.,
Dab I.,
Malfroot A.,
Bonduelle M.,
Liebaers I.
Publication year - 1989
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/bf03335407
Subject(s) - university hospital , obstetrics and gynaecology , medicine , library science , gynecology , family medicine , genetics , biology , pregnancy , computer science
Cystic fibrosis (CF; McKusick 21970) is a common autosomal recessive disease in the Caucasian population with an incidence of approximately 1 in 1600 live births and a carrier frequency of 1 in 20. The biochemical pathology of CF is unknown, but recent work has implicated anion transport across membranes as the physiological basis of the disease (Li et al., 1988).