Open AccessStudy of the effects of chemotherapy on auditory function
Author(s) -
Akshita Dutta,
M.D. Venkatesh,
Richi Kashyap
Publication year - 2005
Publication title -
indian journal of otolaryngology and head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.229
H-Index - 22
eISSN - 2231-3796
pISSN - 0973-7707
DOI - 10.1007/bf03008019
Subject(s) - ototoxicity , medicine , cisplatin , chemotherapy , nephrotoxicity , otorhinolaryngology , tertiary care , sensorineural hearing loss , prospective cohort study , audiology , hearing loss , head and neck surgery , toxicity , surgery
Chemotherapeutic agents are known to cause multiple toxicities such as myelotoxicity, nephrotoxicity and ototoxicity. A prospective study was carried out on 60 patients receiving Cisplatin based chemotherapy in a tertiary care centre. The effects of Cisplatin on auditory function were studied using metabolic, biochemical and audiological parameters. The auditory effects were correlated with the dose and duration of chemotherapy. The study concluded that a significant percentage (15%) of patients who were subjected to chemotherapy based on Cisplatin developed high frequency sensorineural hearing loss which was permanent and irreversible in nature.