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1,3‐Diacyl derivatives of imidazolidine and hexahydropyrimidine: II. Antimycotic activity
Author(s) -
Mod Robert R.,
Magne Frank C.,
Sumrell Gene,
Novak Arthur F.,
Solar James M.
Publication year - 1971
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02883765
Subject(s) - imidazolidine , aspergillus flavus , microsporum gypseum , chemistry , stereochemistry , trichophyton , microbiology and biotechnology , biology , antifungal , food science
Series of 1,3‐diacylated derivatives of imidazolidine and hexahydropyrimidine have been screened for antimycotic activity. Optimum activity was found for the 1,3‐dihexanoyl derivatives in the imidazolidine series, with the higher and lower derivatives being much less active. In the hexahydropyrimidine series the 1,3‐dipentanoyl, ‐dihexanoyl,‐diheptanoyl and ‐dioctanoyl derivatives all exhibited a high degree of inhibition against all four of the test organisms. The latter were Trichophyton rubrum, T violaceum, Microsporum gypseum and Aspergillus flavus .