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Preparation of pyrazolines from methyl 4‐Oxooctadec‐2(e)‐Enoate and their antimicrobial activity
Author(s) -
Agarwal R.,
Rauf A.,
Ahmad M.
Publication year - 1989
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02682619
Subject(s) - hydrazine (antidepressant) , pyrazoline , chemistry , antifungal , antimicrobial , spectral analysis , mass spectrum , organic chemistry , combinatorial chemistry , medicinal chemistry , spectroscopy , chromatography , microbiology and biotechnology , ion , physics , quantum mechanics , biology
Reactions of methyl 4‐oxooctadec‐2( E )‐enoate (I) with hydrazine, phenyl hydrazine and tolylhydrazine provided pyrazoline derivatives (IIa‐c) in excellent yields. The structures of pyrazolines (IIa‐c) were established by IR, NMR and mass spectral analysis. These pyrazoline derivatives showed antifungal and antibacterial activities.