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Metabolism and lipogenic effects of the cyclic monomers of methyl linolenate in the rat
Author(s) -
Iwaoka Wayne T.,
Perkins Edward G.
Publication year - 1978
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02665371
Subject(s) - lipogenesis , chemistry , ingestion , metabolism , urine , medicine , endocrinology , adipose tissue , linolenate , fatty acid , biochemistry , biology
Cyclic fatty acids are absorbed by the rat, partially oxidized to CO 2 , and a portion of the compound, presumably the ring structure, is excreted in the urine. Studies with uniformly labeled cyclic fatty acids showed that ca. 13‐15% of 14 CO 2 is expired by the animal in 48 hr with peak expiration occurring between 4‐6 hr after ingestion. Approximately 40% of the total radioactivity is found in the urine after 48 hr with about 60% of that being excreted within 12 hr after ingestion. Decreased rates of lipogenesis were observed in livers of animals fed 8% and 10% protein and higher levels of cyclic fatty acids. An increased rate of lipogenesis was observed in adipose tissue of animals fed 10% protein and higher levels of cyclic fatty acids.