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High antioxidant activity of extracts obtained from sage by supercritical co 2 extraction
Author(s) -
Djarmati Z.,
Jankov R. M.,
Schwirtlich E.,
Djulinac B.,
Djordjevic A.
Publication year - 1991
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02662161
Subject(s) - chemistry , butylated hydroxytoluene , salvia officinalis , sage , silicic acid , antioxidant , ether , fractionation , chromatography , supercritical fluid , ethyl acetate , supercritical fluid extraction , extraction (chemistry) , organic chemistry , salvia , traditional medicine , medicine , physics , nuclear physics
The ethanolic extract of sage (Salvia officinalis L.) was separated into five fractions through reextraction with supercritical CO 2 . Further fractionation of the most active antioxidant fractions by means of liquid chromatography, with silicic acid as absorbent, yielded 2H‐10,4α‐(epoxy methano)‐phenantren‐12‐one‐1,3,4,9,10,10αhexahydro‐5, 6‐dihydroxy‐9α‐ethoxy‐1,1‐dimethyl‐7‐(1methylethy), (rosmanol‐9‐ethyl ether). The same compound was isolated from the alcoholic extract of the hyssop (Hyssopus officinalis L.). Rosmanol‐9‐ethyl ether was shown to be one of the active antioxidant components in sage and hyssop, with activity much greater than butylated hydroxytoluene (BHT).