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Lipopeptidic surfactants: I. Neutral N‐lauroyl‐I‐arginine dipeptides from pure amino acids
Author(s) -
Infante M. R.,
Molinero J.,
Bosch P.,
Juláa M. R.,
Erra P.
Publication year - 1989
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02660758
Subject(s) - cationic polymerization , pulmonary surfactant , chemistry , monomer , antimicrobial , arginine , organic chemistry , amino acid , polymer , biochemistry
Neutral N α ‐lauroyl‐dipeptides such as N α ‐lauroyl arginylglycine and N α ‐lauroyl‐arginylphenylalanine as methyl ester (cationic surfactants) and free acid (amphoteric surfactants) derivatives have been prepared by synthetic methods. Fundamental surfactant properties and antimicrobial activity have been evaluated. The properties of these compounds have been compared to the properties of the monomer derivatives N α ‐lauroyl‐arginine methyl ester (cationic) and N α ‐lauroyl‐arginine (amphoteric). These new molecules are very soluble in water, good surfactants, and exhibit a good antimicrobial activity, independently of their ionic character.