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Separation of natural polyunsaturated fatty acids by means of lodolactonization
Author(s) -
Gaiday N. V.,
Lmbs A. B.,
Kuklev D. V.,
Latyshev N. A.
Publication year - 1991
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02657614
Subject(s) - docosahexaenoic acid , polyunsaturated fatty acid , eicosapentaenoic acid , chemistry , arachidonic acid , yield (engineering) , fatty acid , organic chemistry , chromatography , enzyme , materials science , metallurgy
Conditions of the iodolactonization reaction (ILreaction) were optimized as a method for separation of natural polyunsaturated fatty acids. The effects of the solvent, temperature and the ratio of components of the iodizing complex KI/I 2 upon the rate of the synthesis of several iodolactones (ILs) in the IL‐reaction are described. It was shown that the rate of formation of γ‐ILs was significantly higher than that for δ‐ILs. This offers opportunity for obtaining pure docosahexaenoic acid (DHA) from fatty acid (FA) concentrates. The possibility for selective reduction of δ‐ILs in the presence of γ‐ILs to yield pure arachidonic acid (AA) or eicosapentaenoic acid (EPA) or fatty acid concentrates has been demonstrated. Preparation of pure AA from a mixture of AA, DHA and other FAs by the IL‐reaction without Chromatographie procedures is described.