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The metabolism of Trans, trans ‐octadecadienoic acid. Incorporation of Trans, trans ‐octadecadienoic acid into the C 20 polyunsaturated acids of the rat
Author(s) -
Knipprath W. G.,
Mead J. F.
Publication year - 1964
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02654879
Subject(s) - polyunsaturated fatty acid , cis–trans isomerism , metabolism , double bond , chemistry , fatty acid , stereochemistry , amino acid , biochemistry , organic chemistry
Trans,trans ‐9,12‐octadecadienoic acid‐1‐C 14 was fed to adult rats. After four hr the animals were killed and the fatty acids isolated from their organ lipids. The 20‐carbon fatty acids were isolated and degraded stepwise. Radioactivity of the degradation products indicated that the fed acid was incorporated into the isolated C 20 acids, mainly eicosatetraenoic acid probably with two trans ‐double bonds, while radio‐activity throughout the chain gave evidence for a synthesis of eicosatrienoic and eicosatetraenoic acid from acetate derived from the fed material. In a separate experiment, unlabeled trans,trans ‐9,12‐octadecadienoic acid was fed to wealing rats for 14 days. Isolation of their fatty acids also gave evidence for the incorporation of the fed acid into eicosatrienoic and eicosatetraenoic acids containing trans double bonds.