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The acute oral toxicity of cottonseed pigment glands and intraglandular pigments
Author(s) -
ElNockrashy A. S.,
Lyman C. M.,
Dollahite J. W.
Publication year - 1963
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02645780
Subject(s) - gossypol , cottonseed , toxicity , cottonseed oil , pigment , corn oil , chemistry , acute toxicity , absorption (acoustics) , food science , biochemistry , organic chemistry , physics , acoustics
Acute oral toxicity studies were carried out on cottonseed pigment glands, gossypol, diaminogossypol and gossypurpurin using rats as experimental animals. It was found that both diaminogossypol and gossypurpurin are considerably less toxic than pure gossypol. The pigment glands were more toxic than gossypol and it was concluded that the toxicity of pigments cannot be accounted for entirely on the basis of their gossypol content. Administration of gossypol with cottonseed oil or Sterculia foetida oil, both of which contain cyclopropene fatty acids, increased the toxicity very slightly over that found when gossypol was administered in corn oil. In the case of corn oil and Sterculia foetida oil, the difference was statistically significant. Less gossypol was also found in the feces when the test dose was given in cottonseed oil or S. foetida oil indicating a possible effect of the cyclopropene fatty acids in increasing gossypol absorption.