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Preparation of fat emulsions for intravenous alimentation
Author(s) -
Geyer Robert P.,
Olsen F. Russell,
Andrus Stephen B.,
Waddell William R.,
Stare Fredrick J.
Publication year - 1955
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02640387
Subject(s) - fat emulsion , emulsion , homogenization (climate) , chromatography , sterility , chemistry , medicine , materials science , food science , parenteral nutrition , surgery , biology , biochemistry , biodiversity , ecology , genetics
Summary Descriptions are given of the high pressure homogenization equipment used and of the actual procedure followed in the preparation of fat emulsions suitable for intravenous nutrition. Such emulsions contain 10–15% oil (w/v) dispersed in particles less than one micron in diameter. They are made under nitrogen and subsequently autoclaved to ensure sterility. Procedures are also given for screening each batch of emulsion by means of tests performed on rats, dogs, and rabbits. Emulsions of the type described have found extensive application in the clinic with a low incidence of unfavorable reactions.