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Interaction of gossypol with the ferrous ion
Author(s) -
Jonassen Hans B.,
Demint Robert J.
Publication year - 1955
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02639702
Subject(s) - ferrous , chemistry , ion , potentiometric titration , inorganic chemistry , sodium , gossypol , aqueous solution , organic chemistry , biochemistry
Summary The preparation of a solution of sodium gossypolate in aqueous acetone has been described. Indications of a 1∶1 mole ratio combination of the gossypolate and ferrous ions were established through conductometric and potentiometric studies in the presence of either chloride or perchlorate anion. Application of the method of continuous variations to differences in the absorption spectra of the two species confirmed the 1∶1 mole ratio of ferrous ion to gossypol. This finding is supported by analytical data. Values of pK for the dissociation constant of ferrous gossypolate, calculated from spectrophotometric measurement, averaged 7.3. Since the peri‐hydroxyls are the most plausible location of the sodium ions in sodium gossypolate, its reaction with ferrous ion results in displacement of the two sodium ions by the ferrous ion.