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Reductive amination of 12‐ketostearic acid
Author(s) -
Freedman Bernard,
Fuller Glenn
Publication year - 1970
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02638991
Subject(s) - yield (engineering) , reductive amination , raney nickel , catalysis , stearic acid , amination , chemistry , hydrogen , ammonia , organic chemistry , nuclear chemistry , materials science , metallurgy
In the preparation of 12‐aminostearic acid by reductive amination of 12‐ketostearic acid, the keto acid is first contacted with ammonia under pressure to produce an intermediate, not isolated, which is then hydrogenated to give the product. Variables such as time and temperature of reaction, hydrogen pressure, and amount and type of catalyst were examined to find optimum conditions for high yield and purity of 12‐amino‐stearic acid. With a hydrogenation pressure of 500 psi and 10% Raney nickel catalyst an essentially quantitative yield of product was obtained having a purity of 94%. With 34% catalyst and 260 psi hydrogen, a 98% yield of 98% pure product was obtained.