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Influence of lauroyl and myristoyl peroxides and oxidized cottonseed oil on depot fat and liver lipid composition
Author(s) -
Kaunitz Hans,
Slanetz C. A.,
Johnson R. E.,
Herb S. F.
Publication year - 1961
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02638433
Subject(s) - cottonseed , chemistry , cottonseed oil , composition (language) , linoleic acid , weanling , food science , corn oil , coconut oil , biochemistry , fatty acid , endocrinology , biology , philosophy , linguistics
In view of the interest in the biological properties of products of fat oxidation, lauroyl and myristoyl peroxides were fed and their nutritional effects compared with those of autoxidized cottonseed oil, which had been analyzed for its composition. Purified diets containing no fat +2% of linoleic acid, 5% lauroyl or myristol peroxide, or 10% oxidized cottonseed oil were fed to weanling male albino rats for 73 to 98 days, after which they were killed and their organs weighed. Their sera, livers, and testicular fat bodies were used for lipid analysis. With peroxides, growth was significantly depressed but not as much as when oxidized cottonseed oil was fed. Analysis of organ weight data showed that peroxides and oxidized cottonseed oil differed in their effects. Animals fed the latter had significantly heavier livers, kidneys, and hearts. The rats fed peroxides were also different from those fed the fat‐free diet and those kept on restricted food intake. Gas chromatographic analysis of the testicular fat bodies revealed a greater deposition of oleate in the animals fed oxidized cottonseed oil, which suggested that these animals were unable to use the oxidized oil for depot fat formation. In the anials fed lauroyl and myristoyl peroxides, appreciable amounts of laurate and myristate, respectively, were found. The composition of the liver neutral fat of the animals fed peroxides was similar to that of the animals fed the low‐fat diet +2%, linoleic acid. Serum cholesterol levels of the rats fed peroxides were about 70 mg. %, and of those fed oxidized cottonseed oil, 53 mg. %. The groups fed peroxides also had significantly higher liver cholesterol levels, which suggests that peroxides and oxidized cottonseed oil differed in their effects on cholesterol formation and transport.