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Conversion of dianilinogossypol to pure gossypol
Author(s) -
King W. H.,
Thurber F. H.
Publication year - 1956
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02638206
Subject(s) - gossypol , chloroform , chemistry , potassium hydroxide , hydrolysis , aniline , chromatography , aqueous solution , salt (chemistry) , yield (engineering) , alkali metal , nuclear chemistry , inorganic chemistry , organic chemistry , materials science , biochemistry , metallurgy
Summary A procedure for the isolation of gossypol (in 86% yield) from dianilinogossypol, together with a procedure for the purification of gossypol, is recorded. Dianilinogossypol is hydrolyzed in alcoholic potassium hydroxide, and the hydrolysis mixture is rapidly cooled and acidified, whereupon the gossypol is precipitated while the aniline remains in solution as the salt. Directions are given for the separation of gossypol from unhydrolyzed dianilinogossypol through partition between aqueous alkali and chloroform.