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Aminimides: I. Antimicrobial effect of some long chain fatty acid derivatives
Author(s) -
Kabara Jon J.,
McKillip William J.,
Sedor Edward A.
Publication year - 1975
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02637734
Subject(s) - antimicrobial , degree of unsaturation , yeast , chemistry , fatty acid , biochemistry , organic chemistry
Aminimides are a new class of surface active agents which have antimicrobial activity. These bipolar compounds have activity against both gran‐positive and yeast organisms. Their activity against gram‐negative organisms is low or absent. The acyl derivatives tested showed maximum activity at chain lengths of C 14 and C 16 . Fatty acid derivatives, shorter (C 16 ), were less active. Unsaturation was an important factor contributing to aminimide activity. Their low toxicity and wide spectrum of antimicrobial activity make aminimides ideal candidates for further investigation.