Premium
Rapid synthesis and purification of vitamin a esters
Author(s) -
AzaisBraesco V.,
Forget A.,
Mercier M.,
Grolier P.
Publication year - 1992
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02637700
Subject(s) - anhydrous , silica gel , chemistry , elution , solvent , chromatography , hexane , organic chemistry , vitamin , column chromatography , ether , retinol , biochemistry
Various esters of retinol (vitamin A) have been synthesized in high yields from fatty acids in one step, at room temperature in the presence of 4‐dimethylaminopyridine and dicyclohexylcarbodiimide. Under anhydrous conditions, this technique avoids the occurrence of undesirable substances. The esters are separated quickly and efficiently from unreacted starting materials by flash chromatography on a silica gel column with a hexane/ether mixture as elution solvent.