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Aminimides: II. Antimicrobial effect of short chain fatty acid derivatives
Author(s) -
Kabara J. J.,
Haitsma G. V.
Publication year - 1975
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02637485
Subject(s) - antimicrobial , bacteria , yeast , chemistry , gram , in vitro , gram negative bacteria , fatty acid , gram positive bacteria , amine gas treating , microbiology and biotechnology , biochemistry , organic chemistry , biology , escherichia coli , gene , genetics
A new family of surfactants, aminimides, has been screened for in vitro antimicrobial activity. These compounds are active against both bacteria and yeast, activity being a function of chain length. Maximum activity for acetimide and acrylimide amine derivatives was extablished with chain lengths of C 14 –C 16 . Homologous compounds with lower or higher chain lengths were less active. While showing low antimicrobial activity against gram negative bacteria, mixtures containing C 12 and C 16 gave good activity against gram negative strains without losing gram positive activity. Aminimides gave low acute LD 50 ’s (200–400 mg/kg) when tested in mice by intraperitoneal injection.