Aminimides: II. Antimicrobial effect of short chain fatty acid derivatives | Zendy

Kabara J. J. | Zendy; Haitsma G. V. | Zendy

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Aminimides: II. Antimicrobial effect of short chain fatty acid derivatives

Author(s) -

Kabara J. J.,

Haitsma G. V.

Publication year - 1975

Publication title -

journal of the american oil chemists' society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.512

H-Index - 117

eISSN - 1558-9331

pISSN - 0003-021X

DOI - 10.1007/bf02637485

Subject(s) - antimicrobial , bacteria , yeast , chemistry , gram , in vitro , gram negative bacteria , fatty acid , gram positive bacteria , amine gas treating , microbiology and biotechnology , biochemistry , organic chemistry , biology , escherichia coli , gene , genetics

A new family of surfactants, aminimides, has been screened for in vitro antimicrobial activity. These compounds are active against both bacteria and yeast, activity being a function of chain length. Maximum activity for acetimide and acrylimide amine derivatives was extablished with chain lengths of C 14 –C 16 . Homologous compounds with lower or higher chain lengths were less active. While showing low antimicrobial activity against gram negative bacteria, mixtures containing C 12 and C 16 gave good activity against gram negative strains without losing gram positive activity. Aminimides gave low acute LD 50 ’s (200–400 mg/kg) when tested in mice by intraperitoneal injection.

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