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Eicosapentaenoic acid suppressed the proliferation of vascular smooth muscle cells through modulation of various steps of growth signals
Author(s) -
Terano T.,
Shiina T.,
Tamura Y.
Publication year - 1996
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02637096
Subject(s) - eicosapentaenoic acid , vascular smooth muscle , polyunsaturated fatty acid , docosahexaenoic acid , platelet derived growth factor receptor , signal transduction , cell growth , platelet derived growth factor , clinical chemistry , biochemistry , microbiology and biotechnology , growth factor , lipidology , biology , receptor , chemistry , fatty acid , endocrinology , smooth muscle
Among fatty acids, only n‐3 polyunsaturated fatty acids such as eicosapentanenoic acid (EPA) and docosahexaenoic acid (DHA) inhibited the proliferation of vascular smooth muscle cells. DHA was less effective than EPA. To clarify the anti‐proliferative effect of n‐3 polyunsaturated fatty acid, we have explored the effect of EPA on the signal transduction pathway of platelet derived growth factor (PDGF). EPA inhibited PDGF binding on its receptor and activation of protein kinase C. EPA also suppressed c‐fos mRNA expression, one of immediate early genes, through partly inhibiting c‐fos transcription. These data revealed that EPA could inhibit vascular smooth muscle cell proliferation through modulating various steps of the signal transduction by PDGF.