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Role of lipids in development of noninsulin‐dependent diabetes mellitus: Lessons learned from pima indians
Author(s) -
Tataranni P. A.,
Baier L. J.,
Paolisso G.,
Howard B. V.,
Ravussin E.
Publication year - 1996
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02637088
Subject(s) - nefa , medicine , diabetes mellitus , dyslipidemia , insulin resistance , endocrinology , lipidology , clinical chemistry , fatty acid , pathogenesis , hyperlipidemia , insulin , chemistry , biochemistry
We studied the role of lipids in the pathogenesis of nonlinsulin‐dependent diabetes mellitus (NIDDM) in Pima Indians. High plasma levels of nonesterified fatty acid (NEFA) predicted development of NIDDM, but this effect cannot entirely be explained by the glucose‐fatty acid cycle. Dyslipidemia, although often associated with diabetes, did not seem to predict NIDDM, and might rather be associated with or the consequence of insulin resistance. In some individuals, a single amino acid substitution in the intestinal fatty acid binding protein could result, in increased rates of intestinal absorption of dietary NEFA and thereby contribute to increased lipid‐oxidation rates and insulin resistance.