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Thioesterification of platelet proteins with saturated and polyunsaturated fatty acids
Author(s) -
Laposata Michael,
Muszbek Laszlo
Publication year - 1996
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02637079
Subject(s) - thioester , chemistry , polyunsaturated fatty acid , biochemistry , platelet , glycoprotein , von willebrand factor , fatty acid , lipidology , biology , enzyme , immunology
We have demonstrated that more than 20 platelet proteins can be acylated with fatty acids via thioester linkages. These include the glycoprotein IX beta chain of glycoprotein Ib, components of the von Willebrand factor receptor on the platelet surface, P‐selectin, and α subunits of G z , G q , and G i . Our studies have shown that platelet proteins can be posttranslationally acylated in thioester linkages not only with palmitate but with myristate and also with the eicosanoid precursor fatty acids arachidonate and eicosapentaenoate. Thioesterification of platelet proteins with fatty acids other than palmitate may have significant functional consequences for reversible binding of proteins to membranes.