Premium
Cholesterol turnover in the central nervous system
Author(s) -
Nicholas Harold J.
Publication year - 1965
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02636893
Subject(s) - metabolite , fractionation , central nervous system , cholesterol , chemistry , biochemistry , turnover , oxidative phosphorylation , chromatography , biology , endocrinology , management , economics
Immature rat brains were examined for a metabolite of cholesterol which could conceivably form in the central nervous system as a result of cholesterol turnover. A basic assumption was made that an acidic product would be formed, preferentially by oxidative degradation of the cholesterol side chain. Chemical fractionation of brain tissue and thin‐layer chromatography of an appropriate acidic fraction indicated the presence of a monohydroxy steroidal acid(s) which remains to be positively identified. Preliminary tracer experiments did not clarify the origin of the unidentified metabolite.