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Long‐chain carboxylic acids containing ether linkage III. The antibacterial and antifungal activities of the amine salts of some B ‐alkoxypropionic acids
Author(s) -
Abe Y.,
Osanai Shuichi
Publication year - 1969
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02636866
Subject(s) - epidermophyton floccosum , chemistry , amine gas treating , organic chemistry , triethanolamine , trichophyton , salt (chemistry) , alkoxy group , antifungal , alkyl , microbiology and biotechnology , biology , analytical chemistry (journal)
Octylamine, dodecylamine, octadecylamine and triethanolamine salts of β ‐dodecyloxy‐ and β ‐tetradecyloxypropionic acids, without or with one and with two oxyethylene groups between the alkoxy group and the propionic acid group, were prepared and examined as the growth inhibiting agents against Staphylococcus aureus and Penicillium . Some of them were also tested against Trichophyton asteroides, T. interdigitale, T. granulosus, Epidermophyton floccosum and Microsporum canis . The effects of the alkyloxy, oxyethylene and amine groups on antibacterial and antifungal activities were determined. The dodecyl radical was more potent than the tetradecyloxy radical. The enhancing effect of the oxyethylene group was obscure in the amine salts. The most effective amine was dodecylamine and its salt of β ‐dodecyloxypropionic acid showed almost the same effectiveness as that of its mercury salt against Trichophyton . As for the soluble amine salts, it was confirmed that their surface activities had nothing to do with their antibacterial and fungicidal powers.