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Effect of various parameters on sodium dodecyl sulfate (SDS) flux through a collagen membrane
Author(s) -
Garcia M. T.,
Sanchez Leal J.,
Ribosa I.
Publication year - 1992
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02635870
Subject(s) - pulmonary surfactant , sodium dodecyl sulfate , ionic strength , chemistry , diffusion , chromatography , membrane , absorption (acoustics) , sodium , monomer , ionic bonding , sulfate , chemical engineering , materials science , polymer , biochemistry , ion , organic chemistry , aqueous solution , composite material , thermodynamics , physics , engineering
The influence of various experimental parameters on the flux of sodium dodecyl sulfate (SDS) through a collagen membrane has been studied. The variables evaluated were donor concentration, time, temperature, pH and ionic strength. Data on the influence of both surfactant concentration and time on surfactant diffusion through the collagen film allow one to postulate a diffusion process mainly of the monomeric type. This diffusion mechanism based on surfactant monomers has been corroborated by studying the effect of ionic strength. This in vitro technique could be a useful tool to predict the effect of diverse experimental parameters on the percutaneous absorption of surfactants.