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Triglyceride alterations in normal and reticuloendothelial stimulated rats following carbon tetrachloride
Author(s) -
Di Luzio N. R.
Publication year - 1962
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02635816
Subject(s) - carbon tetrachloride , triglyceride , medicine , endocrinology , mononuclear phagocyte system , chemistry , cholesterol , pathology , organic chemistry
The administration of a single dose of carbon tetrachloride to normal rats was associated with a significant increase in liver triglyceride concentration and a pronounced reduction in plasma triglycerides. The evaluation of hepatic activity indicated that the removal of bromsulphalein from plasma was significantly impaired while phagocytic function remained unaltered. Animals with pronounced hyperplasia and hyperfunction of the reticulo‐endothelial system induced by zymosan were less susceptible to carbon tetrachloride, manifesting a smaller degree of liver triglyceride accumulation and maintenance of a normal plasma triglyceride level. The possible significance of these findings are discussed.