Premium
Studies on brain sterols in normal and pathological conditions
Author(s) -
Paoletti R.,
Fumagalli R.,
Grossi E.,
Paoletti P.
Publication year - 1965
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02635575
Subject(s) - desmosterol , propylthiouracil , sterol , nervous tissue , endocrinology , brain tissue , pathological , biology , guinea pig , medicine , cholesterol , neuroscience , thyroid
Desmosterol (24‐dehydrocholesterol), a normal constituent of developing brain, rapidly disappears during the prenatal and postnatal development, according to the degree of maturation, in all species considered (chicken, mouse, rat, guinea pig, man). During brain maturation, desmosterol concentrations are sensitive to treatments with drugs interfering with sterol synthesis (Triparanol) or with nervous tissue differentiation (thyroxine and propylthiouracil). Desmosterol has been also detected in some experimental and human glial tumors, and the concentra. in the tumor may be specifically increased in the tumoral tissue by the administration of Triparanol.