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The effect of ammoniation upon ricinine in castor meal
Author(s) -
Hinkson J. W.,
Elliger C. A.,
Fuller G.
Publication year - 1972
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02633795
Subject(s) - chemistry , meal , ammonia , lactate dehydrogenase , biochemistry , food science , enzyme
When castor meal is detoxified by treatment with ammonia to destroy ricin and various allergens the amount of ricinine, a toxic pyridone normally present in castor, is also reduced by about 25%. It was shown that the majority of ricine loss can be accounted for by the production of 4‐amino‐3‐cyano‐N‐methyl‐2‐pyridone, a product formed by displacement of the original methoxyl group of ricinine with ammonia. In vitro enzymatic studies have demonstrated that neither this compound nor ricinine significantly affects lactate dehydrogenase. Another possible derivative of ricinine formed from ammoniation, 4‐amino‐3‐carboxamido‐N‐methyl‐2‐pyridone, which was not found in ammoniated castor meal, did inhibit lactate dehydrogenase.