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Metabolism of ortho ‐alkylbenzenealkanoic acid in rats
Author(s) -
Van Tilborg H.,
De Bruijn J.,
Gottenbos J. J.,
Koch G. K.
Publication year - 1970
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02632960
Subject(s) - chemistry , metabolism , urine , linseed oil , excretion , beta oxidation , ring (chemistry) , metabolic pathway , lipid metabolism , fatty acid , aromaticity , biochemistry , chromatography , organic chemistry , molecule
Aromatic fatty acids with 18 C‐atoms, as isolated from cyclized linseed oil, were labeled with 3 H in the aromatic ring by isotopic exchange. Doses of 50 mg/kg body weight were almost quantitatively absorbed by rats and excretion of metabolites via the urine was rapid (up to 95% within 30 hr). The retention curve consisted of two branches, which indicates that part of the aromatic acids are taken up into the lipid pool. This was confirmed by analysis of body lipids. The metabolic pathways involved in the degradation of the aromatic fatty acids are β‐oxidation, ω‐oxidation and (ω‐1)‐oxidation.