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Lipid peroxidation in vivo
Author(s) -
Witting Lloyd A.
Publication year - 1965
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02632443
Subject(s) - autoxidation , polyunsaturated fatty acid , lipid peroxidation , tocopherol , in vivo , chemistry , kinetics , biochemistry , selenium , antioxidant , in vitro , vitamin e , fatty acid , biology , organic chemistry , microbiology and biotechnology , physics , quantum mechanics
Under a rather rigidly defined set of empirical conditions, the kinetics of production of a specific tocopherol‐deficiency sign, creatinuria, in the rat were comparable to the kinetics of the autoxidation of pure polyunsaturated fatty acids in model systems in vitro . The tocopherol requirement of the rat under these conditions was clearly related to the kinetics of lipid peroxidation. Dietary, biologically available selenium decreased the rate of production of creatinuria and the rate of disappearance of tissue polyunsaturated fatty acids (PUFA) equally and, therefore, may have functioned as a lipid antioxidant in vivo . A hypothetical model of lipid peroxidation was prepared in an attempt to describe the interaction of PUFA, tocopherol, biologically available selenium, and sulfur amino acids.