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Preparation of pure gossypol from dianilinogossypol
Author(s) -
Smith F. H.
Publication year - 1960
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/bf02631767
Subject(s) - gossypol , petroleum ether , ether , acetic acid , chemistry , hydrolysis , ethanol , recrystallization (geology) , crystallization , organic chemistry , yield (engineering) , acid hydrolysis , ethyl acetate , chromatography , biochemistry , materials science , extraction (chemistry) , paleontology , metallurgy , biology
Summary A simple method has been developed for the acid hydrolysis of dianilinogossypol, resulting in gossypol yields of about 86%. The gossypol may be readily purified by recrystallization as gossypol‐acetic acid from a mixture of ethyl ether and acetic acid. After removal of the acetic acid the gossypol may be crystallized either from a mixture of ether and light petroleum ether or from a mixture of ether, ethanol, and water. Crystallization from the latter mixture results in a yield of about 75% of gossypol, based on the amount of dianilinogossypol hydrolyzed, with a high degree of purity as is indicated by spectrophotometric and titrimetric methods.